深部脑刺激改善神经退行性疾病认知障碍：神经发生和电路再激活。
Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation.
机构信息
1 Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan.
2 Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
出版信息
Cell Transplant. 2019 Jul;28(7):813-818. doi: 10.1177/0963689718804144. Epub 2018 Oct 9.
Acute (e.g., traumatic brain injury or stroke) and chronic (e.g., dementia or Parkinson's disease dementia) neurological disorders that involve cognitive impairment and dysfunctional neural circuits always lead to a dreadful and costly experience for patients and their families. The application of deep brain stimulation for the treatment of neuropsychiatric disorders has shown great potential to modulate pathological neural circuits and trigger endogenous neurogenesis. We summarize several important clinical and translational studies that utilize deep brain stimulation to improve cognition based on the potentiation of neural plasticity and neurogenesis. In addition, we discuss the neuroanatomy and cerebral circuits implicated in such studies as well as the potential mechanisms underlying therapeutic benefits.
急性（例如，创伤性脑损伤或中风）和慢性（例如，痴呆或帕金森病痴呆）神经障碍会导致认知障碍和功能失调的神经回路，这对患者及其家属来说总是一场可怕且代价高昂的经历。深部脑刺激在治疗神经精神疾病方面的应用显示出了调节病理性神经回路和触发内源性神经发生的巨大潜力。我们总结了几项重要的临床和转化研究，这些研究利用深部脑刺激来改善认知，其基础是增强神经可塑性和神经发生。此外，我们还讨论了这些研究中涉及的神经解剖结构和大脑回路，以及治疗益处的潜在机制。
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