Emini E A, Luka J, Armstrong M E, Keller P M, Ellis R W, Pearson G R
Virology. 1987 Apr;157(2):552-5. doi: 10.1016/0042-6822(87)90300-x.
The Epstein-Barr virus (EBV) antigenic homologue of the varicella-zoster virus glycoprotein II and the herpes simplex virus (HSV) glycoprotein B (gB) was identified through cross-reactivity with anti-glycoprotein II and anti-glycoprotein B peptide sera. The homologue is the previously characterized EBV glycoprotein, with an apparent molecular weight of 125,000 Da, which is synthesized late during productive EBV infection and appears to be encoded by the BamHI A EBV fragment. This glycoprotein, but not other EBV proteins, reacted with the antisera in immunoprecipitation experiments and by ELISA. In addition, absorption of the sera with the purified EBV 125-kDa glycoprotein removed the cross-reacting antibody. Whether the EBV gB homologue has the same biological functions associated with HSV gB has yet to be determined.
通过与抗水痘-带状疱疹病毒糖蛋白II和抗单纯疱疹病毒（HSV）糖蛋白B（gB）肽血清的交叉反应，鉴定出了Epstein-Barr病毒（EBV）与水痘-带状疱疹病毒糖蛋白II和单纯疱疹病毒糖蛋白B的抗原同源物。该同源物是先前已鉴定的EBV糖蛋白，表观分子量为125,000 Da，在EBV增殖性感染后期合成，似乎由BamHI A EBV片段编码。在免疫沉淀实验和酶联免疫吸附测定（ELISA）中，该糖蛋白而非其他EBV蛋白与抗血清发生反应。此外，用纯化的EBV 125-kDa糖蛋白吸收血清可去除交叉反应抗体。EBV gB同源物是否具有与HSV gB相关的相同生物学功能尚待确定。
