Saqallah Fadi G, Hamed Wafaa M, Talib Wamidh H
Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, 11931 Amman, Jordan.
Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, 11931 Amman, Jordan.
Sci Pharm. 2018 Oct 7;86(4):E45. doi: 10.3390/scipharm86040045.
Mediterranean-native perennial plant was scrutinized in this study for its antioxidant activity and its total phenolic content in order to test for the plant's wound-healing capability. The traditional uses of this plant to treat gum scurvy, various tumors, ulcers, and hemorrhoids were the main idea behind this study. Leaves and flowers of the were extracted by maceration. Pilot qualitative phytochemical tests were made to check the presence of various secondary metabolites. Quantitatively, the flowers' macerate indicated superlative results regarding antioxidant activity and total phenolic content. However, the in vivo wound-healing capability study was made using 30 Wistar strain albino rats. This innovative part of the study revealed that the healing power of the flowers' extract ointment (5% /) was superior compared to the leaves' extract (5% /) and the positive-control ointments (MEBO) (1.5% /) ( ≤ 0.001). This activity was assessed by visual examination, wound-length measurement, and estimation of hydroxyproline content. is a promising plant to be considered for wound healing. However, further testing (including histological examination and high-performance liquid chromatography (HPLC) analysis) is necessary to understand more about its mechanisms of action.
本研究对一种地中海原生多年生植物的抗氧化活性和总酚含量进行了详细研究，以测试该植物的伤口愈合能力。该植物用于治疗牙龈坏血病、各种肿瘤、溃疡和痔疮的传统用途是本研究的主要出发点。通过浸渍法提取该植物的叶子和花朵。进行了初步定性植物化学测试，以检查各种次生代谢产物的存在。在定量方面，花朵浸出液在抗氧化活性和总酚含量方面显示出优异的结果。然而，体内伤口愈合能力研究是使用30只Wistar品系白化大鼠进行的。该研究的这一创新部分表明，花朵提取物软膏（5%/）的愈合能力优于叶子提取物（5%/）和阳性对照软膏（MEBO）（1.5%/）（P≤0.001）。通过视觉检查、伤口长度测量和羟脯氨酸含量估计来评估这种活性。该植物有望用于伤口愈合。然而，需要进一步测试（包括组织学检查和高效液相色谱（HPLC）分析）以更深入了解其作用机制。
