Ipas Nepal, Kathmandu, 44600, Nepal.
Institute for Health and Sport (IHES), Victoria University, Melbourne, 1300 VIC UNI, Australia.
Sci Rep. 2018 Oct 9;8(1):14995. doi: 10.1038/s41598-018-33177-5.
Metabolic syndrome (MetS) increases the risk of cardiovascular diseases and diabetes mellitus. This study is designed to assess the prevalence and determinants of MetS among Nepalese adults from a nationally representative study. This study is based on Stepwise Approach to Surveillance (STEPS) Survey from Nepal. This survey was done among 4200 adults aged 15-69 years from 210 clusters selected proportionately across Nepal's three ecological zones (Mountain, Hill and Terai). Subsequently, using systematic sampling, twenty households per cluster and one participant per household were selected. The overall prevalence of MetS is 15% and 16% according to Adult Treatment Panel III (ATP III) and International Diabetes Federation (IDF) criteria respectively. A triad of low HDL-C, abdominal obesity and high BP was the most prevalent (8.18%), followed by abdominal obesity, low HDL-C cholesterol and high triglycerides (8%). Less than two percent of participants had all the five components of the syndrome and 19% of participants had none. The prevalence steadily rose across the age group with adults aged 45-69 years having the highest prevalence (28-30%) and comparable prevalence across two definitions of MetS. A notably high burden for females, urban, hill or Terai resident were seen among other factors.
代谢综合征（MetS）会增加心血管疾病和糖尿病的风险。本研究旨在评估尼泊尔成年人代谢综合征的患病率及其决定因素，该研究基于尼泊尔的逐步监测方法（STEPS）调查。该调查在尼泊尔三个生态区（山区、丘陵和特莱）中按比例选择的 210 个集群中，对 4200 名 15-69 岁成年人进行了调查。随后，采用系统抽样方法，每个集群选择 20 户家庭，每户选择 1 名参与者。根据成人治疗专家组 III（ATP III）和国际糖尿病联合会（IDF）标准，代谢综合征的总患病率分别为 15%和 16%。三联征低 HDL-C、腹部肥胖和高血压是最常见的（8.18%），其次是腹部肥胖、低 HDL-C 胆固醇和高甘油三酯（8%）。不到 2%的参与者有该综合征的所有五个组成部分，19%的参与者没有任何一个组成部分。随着年龄组的增加，患病率稳步上升，45-69 岁的成年人患病率最高（28-30%），两种代谢综合征定义的患病率相当。女性、城市居民、丘陵区或特莱区居民等其他因素的负担明显较高。
