Zhang Jianying, Nie Daibang, Rocha Jorge L, Hogan MaCalus V, Wang James H-C
MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Bioengineering, University of Pittsburgh, PA, USA.
J Tissue Eng. 2018 Oct 3;9:2041731418801103. doi: 10.1177/2041731418801103. eCollection 2018 Jan-Dec.
In this study, we report that human plantar fascia consists of two distinct tissues with differential structural properties. These tissues also contain stem/progenitor cells with differential biological properties. The mechanobiological responses of these two plantar fascia stem cells also differ in terms of expression of collagen I and IV, non-ligament-related genes, and proinflammatory genes. The production of inflammatory agents (prostaglandin E, interleukin-6) and matrix degradative enzymes (matrix metalloproteinase-1, matrix metalloproteinase-2) are also different between the two types of plantar fascia stem cells. Based on the findings from this study, we suggest that plantar fasciitis results from the aberrant mechanobiological responses of the stem cells from plantar fascia sheath and core tissues. Our findings may also be used to devise tissue engineering approaches to treat plantar fascia injury effectively.
在本研究中，我们报告称人类足底筋膜由两种具有不同结构特性的不同组织组成。这些组织还含有具有不同生物学特性的干/祖细胞。这两种足底筋膜干细胞的机械生物学反应在I型和IV型胶原蛋白、非韧带相关基因以及促炎基因的表达方面也存在差异。两种类型的足底筋膜干细胞之间炎症介质（前列腺素E、白细胞介素-6）和基质降解酶（基质金属蛋白酶-1、基质金属蛋白酶-2）的产生也有所不同。基于本研究的结果，我们认为足底筋膜炎是由足底筋膜鞘和核心组织干细胞异常的机械生物学反应引起的。我们的研究结果也可用于设计组织工程方法来有效治疗足底筋膜损伤。
