一种花青素与益生元混合物对肥胖男性和女性受试者肠道环境的功效

Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects.

作者信息

Hester Shelly N, Mastaloudis Angela, Gray Russell, Antony Joseph M, Evans Mal, Wood Steven M

机构信息

Pharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USA.

KGK Science Inc., 255 Queens Avenue, Suite 1440, London, Ontario, Canada N6A 5R8.

出版信息

J Nutr Metab. 2018 Sep 13;2018:7497260. doi: 10.1155/2018/7497260. eCollection 2018.

BACKGROUND

Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem.

OBJECTIVES

An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation.

RESULTS

After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes ( < 0.001) and Actinobacteria ( < 0.001) and a significant increase in Bacteroidetes ( < 0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating ( < 0.05), gas (=0.035), and abdominal pain (=0.015) as well as significant improvements in stool consistency ( < 0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (=0.107). The supplement was safe and well tolerated.

CONCLUSIONS

The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.

背景

花青素和益生元可能通过调节微生物群和肠道生态系统来影响整体健康。

目的

设计一项针对无并发症肥胖男性和女性志愿者的为期8周的开放标签研究，以研究花青素和益生元混合物在调节肠道微生物群和肠道炎症方面的功效。

结果

每日补充8周后，参与者的厚壁菌门（<0.001）和放线菌门（<0.001）显著减少，拟杆菌门显著增加（<0.001）。腹胀严重程度（<0.05）、气体（=0.035）和腹痛（=0.015）减轻，粪便稠度显著改善（<0.05），证明肠道习惯得到改善。最后，炎症标志物粪便钙卫蛋白出现非显著下降（=0.107）。该补充剂安全且耐受性良好。