6-β-碘青霉烷酸作为β-内酰胺酶分类的探针。
6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.
作者信息
De Meester F, Frère J M, Waley S G, Cartwright S J, Virden R, Lindberg F
出版信息
Biochem J. 1986 Nov 1;239(3):575-80. doi: 10.1042/bj2390575.
Abstract
An inactivator of serine beta-lactamases, 6 beta-iodopenicillanate, can be utilized as a probe in the classification of beta-lactamases. It is a substrate for class-B Zn2+-containing beta-lactamase II. Although it inactivates enzymes from both classes A and C, it is much more efficient for the former group, with which it sometimes interacts following a branched pathway. On the basis of these observations, predictions are made concerning the class to which several enzymes belong.
摘要
丝氨酸β-内酰胺酶的一种失活剂，6β-碘青霉烷酸，可作为β-内酰胺酶分类的探针。它是B类含锌β-内酰胺酶II的底物。虽然它能使A类和C类的酶失活，但对前一组酶的作用效率要高得多，它有时会通过一条分支途径与前一组酶相互作用。基于这些观察结果，对几种酶所属的类别进行了预测。
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