斯氏普罗威登斯菌对头孢他啶和氨曲南的耐药性：一种天然TEM衍生的超广谱β-内酰胺酶TEM-60的特性
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60.
作者信息
Franceschini N, Perilli M, Segatore B, Setacci D, Amicosante G, Mazzariol A, Cornaglia G
机构信息
Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi dell'Aquila, Italy.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1459-62. doi: 10.1128/AAC.42.6.1459.
Abstract
A plasmid-encoded beta-lactamase produced from a clinical strain of Providencia stuartii has been purified and characterized. The gene coding for the beta-lactamase was cloned and sequenced. It appears to be a new natural TEM-derived enzyme, named TEM-60. Point mutations (Q39K, L51P, E104K, and R164S) are present with respect to the TEM-1 enzyme; the mutation L51P has never been previously reported, with the exception of the chromosomally encoded extended-spectrum beta-lactamase PER-1. Kinetic parameters relative to penicillins, cephalosporins, and monobactams other than mechanism-based inactivators were related to the in vitro susceptibility phenotype.
摘要
从普罗威登斯菌临床菌株中产生的一种质粒编码β-内酰胺酶已被纯化和鉴定。编码该β-内酰胺酶的基因已被克隆和测序。它似乎是一种新的天然TEM衍生酶，命名为TEM-60。相对于TEM-1酶存在点突变（Q39K、L51P、E104K和R164S）；除了染色体编码的超广谱β-内酰胺酶PER-1外，L51P突变以前从未被报道过。相对于除基于机制的失活剂之外的青霉素、头孢菌素和单环β-内酰胺类的动力学参数与体外药敏表型相关。
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