Otogo N'Nang Elvis, Le Pogam Pierre, Ndong Mba Thiery, Sima Obiang Cédric, Mouray Elisabeth, Grellier Philippe, Kumulungui Brice, Champy Pierre, Beniddir Mehdi A
Équipe "Chimie des Substances Naturelles" BioCIS, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
Laboratoire de Chimie des Substances Naturelles, Département Science Fondamentale de l'Ingénieur (INSAB), Université des Sciences et Techniques de Masuku, BP 901 Franceville, Gabon.
J Nat Prod. 2021 Apr 23;84(4):1409-1413. doi: 10.1021/acs.jnatprod.1c00143. Epub 2021 Apr 7.
Hemitheion (), a new sulfur-containing vobasane-type indole alkaloid, was isolated, together with three known compounds, vobasine (), gelsedine (), and gelsemicine (), from the alkaloid extract of the stems of Didr. (Gelsemiaceae). Compound could be straightforwardly isolated. Its structure was elucidated by a combination of spectroscopic methods. Besides corresponding to a formerly postulated biosynthetic intermediate toward theionbrunonines, hemitheion () stands among the few monomeric vobasanes lacking an oxygen at C-3. Hemitheion () showed moderate antiplasmodial activity in the micromolar range against the strain FcB1 of and no cytotoxic activity against the MRC-5 cell line at 20 μM.
从胡蔓藤科植物胡蔓藤（Didr.）茎的生物碱提取物中分离出一种新的含硫沃巴烷型吲哚生物碱——半胱氨酸（Hemitheion），以及三种已知化合物——沃巴辛（vobasine）、格塞丁（gelsedine）和格塞米辛（gelsemicine）。化合物可以直接分离得到。其结构通过多种光谱方法确定。除了对应于之前推测的向ionbrunonines生物合成中间体之外，半胱氨酸（Hemitheion）是少数在C-3位缺乏氧原子的单体沃巴烷之一。半胱氨酸（Hemitheion）在微摩尔范围内对恶性疟原虫FcB1株表现出中等抗疟活性，在20 μM时对MRC-5细胞系无细胞毒性活性。
