输卵管癌相关的 Leser-Trelát 征和恶性黑棘皮病。
The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma.
机构信息
Departments of Dermatology and Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, and the Department of Dermatology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
出版信息
Obstet Gynecol. 2018 Nov;132(5):1116-1119. doi: 10.1097/AOG.0000000000002920.
BACKGROUND
The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses.
CASE
A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium.
CONCLUSION
The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.
背景
Leser-Trelát 征具有争议性，在妇科恶性肿瘤中很少见。其特征为脂溢性角化病迅速出现或增大。
病例
一名 78 岁女性因不明原因体重减轻和新发红斑性斑块出现就诊，斑块伴皮肤增厚、呈粗皱状，胸部和背部有黏着性棕色蜡样丘疹。她的症状提示副肿瘤性发疹；检查发现 CA 125 水平升高，腹部计算机断层扫描显示卵巢肿块。剖腹探查显示 IIIC 期输卵管浆液性腺癌和同步子宫内膜低级别子宫内膜样腺癌。
结论
Leser-Trelát 征可与输卵管癌相关。当识别出该征时，副肿瘤性皮肤病可促使临床医生开始进行隐匿性恶性肿瘤的检查。
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