Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119, the Western Road of the southern 4th Ring Road, Beijing, 100070, China.
Sci Rep. 2021 Jan 12;11(1):623. doi: 10.1038/s41598-020-79845-3.
Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric insular lobe compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with insular lobe DLGGs during functional compensation. Thirty-five patients with insular DLGGs were classified into the left (insL, n = 16) and right groups (insR, n = 19), and 33 healthy subjects were included in the control group. Resting state functional magnetic resonance imaging was used to generate functional connectivity (FC), and network topological properties were evaluated using graph theoretical analysis based on FC matrices. Network-based statistics were applied to compare differences in the FC matrices. A false discovery rate was applied to correct the topological properties. There was no difference in the FC of edges between the control and insL groups; however, the nodal shortest path length of the right insular lobe was significantly increased in the insL group compared to the control group. Additionally, FC was increased in the functional edges originating from the left insular lobe in the insR group compared to the control group. Moreover, there were no differences in topological properties between the insR and control groups. The contralesional insular lobe is crucial for network alterations. The detailed patterns of network alterations were different depending on the affected hemisphere. The observed network alterations might be associated with functional network reorganization and functional compensation.
弥漫性低级别胶质瘤（DLGGs）在岛叶生长，通过增加皮质体积来代偿损伤功能，导致对侧半球岛叶的代偿。然而，岛叶 DLGG 患者在功能代偿过程中功能网络如何改变仍不清楚。将 35 名岛叶 DLGG 患者分为左侧组（insL，n=16）和右侧组（insR，n=19），并纳入 33 名健康受试者作为对照组。采用静息态功能磁共振成像生成功能连接（FC），并基于 FC 矩阵进行图论分析评估网络拓扑性质。采用基于网络的统计学方法比较 FC 矩阵的差异。应用假发现率校正拓扑性质。对照组和 insL 组之间的边缘 FC 没有差异；然而，与对照组相比，insL 组右侧岛叶的节点最短路径长度显著增加。此外，与对照组相比，insR 组起源于左侧岛叶的功能边缘的 FC 增加。此外，insR 组和对照组之间的拓扑性质没有差异。对侧岛叶对于网络改变至关重要。病变侧半球的不同影响导致了网络改变的详细模式不同。观察到的网络改变可能与功能网络重组和功能代偿有关。
