Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carcinogenesis. 2018 Dec 13;39(11):1311-1319. doi: 10.1093/carcin/bgy133.
Prostate cancer remains the second most prevalent cancer in men. Its incidence, progression and mortality profiles vary significantly by race and ethnicity, with African-American men having the highest incidence rate and mortality rate in the world. Although these disparities can be partially explained by socioeconomic factors, the underlying molecular causes are complex and require careful research. A considerable amount of literature exists, supporting the association between mitochondrial health and the incidence, aggression and risk of prostate cancer. Genetic alterations in mitochondrial DNA are frequent in prostate cancer; therefore, the resulting mitochondrial dysfunction and metabolic dysregulation may contribute to or indicate oncogenesis. Many of the prominent features of cancer cells are also closely related to mitochondrial functions, such as resistance to apoptosis, excess reactive oxygen species production and altered oxidative phosphorylation. In addition, prostate cancer ethnic disparity is influenced by environmental and lifestyle factors, which involves differences in mitochondrial metabolism and retrograde signaling events.
前列腺癌仍然是男性中第二大常见癌症。其发病率、进展和死亡率特征因种族和民族而异，非裔美国男性的发病率和死亡率在全球最高。尽管这些差异部分可以用社会经济因素来解释，但潜在的分子原因很复杂，需要仔细研究。大量文献支持线粒体健康与前列腺癌的发生、侵袭性和风险之间的关联。线粒体 DNA 的遗传改变在前列腺癌中很常见；因此，由此产生的线粒体功能障碍和代谢失调可能有助于或表明肿瘤发生。癌细胞的许多突出特征也与线粒体功能密切相关，例如对细胞凋亡的抵抗、过量的活性氧产生和氧化磷酸化的改变。此外，前列腺癌的种族差异受环境和生活方式因素的影响，这涉及到线粒体代谢和逆行信号事件的差异。
