HUGO Gene Nomenclature Committee, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire CB10 1SD, UK.
Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire CB2 0AW, UK.
Nucleic Acids Res. 2021 Jan 8;49(D1):D939-D946. doi: 10.1093/nar/gkaa980.
The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 42,000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. While we still update placeholder and problematic symbols, we are working towards stabilizing symbols where possible; over 2000 symbols for disease associated genes are now marked as stable in our symbol reports. All of our data is available at the HGNC website https://www.genenames.org. The Vertebrate Gene Nomenclature Committee (VGNC) was established to assign standardized nomenclature in line with human for vertebrate species lacking their own nomenclature committee. In addition to the previous VGNC core species of chimpanzee, cow, horse and dog, we now name genes in cat, macaque and pig. Gene groups have been added to VGNC and currently include two complex families: olfactory receptors (ORs) and cytochrome P450s (CYPs). In collaboration with specialists we have also named CYPs in species beyond our core set. All VGNC data is available at https://vertebrate.genenames.org/. This article provides an overview of our online data and resources, focusing on updates over the last two years.
人类基因命名委员会（HGNC）位于欧洲生物信息学研究所（EMBL-EBI），负责为人类基因分配独特的符号和名称。我们目前的数据库中有超过 42000 个经过批准的基因符号，其中超过 19000 个是编码蛋白质的基因。虽然我们仍在更新占位符和有问题的符号，但我们正在努力尽可能稳定符号；在我们的符号报告中，现在有超过 2000 个与疾病相关的基因符号被标记为稳定。我们所有的数据都可在 HGNC 网站 https://www.genenames.org 上获得。脊椎动物基因命名委员会（VGNC）成立的目的是为缺乏自己命名委员会的脊椎动物物种分配标准化的命名法。除了之前的 VGNC 核心物种黑猩猩、牛、马和狗外，我们现在还为猫、猕猴和猪命名基因。VGNC 增加了基因群，目前包括两个复杂家族：嗅觉受体（ORs）和细胞色素 P450s（CYPs）。我们还与专家合作，为核心物种以外的物种命名了 CYPs。所有的 VGNC 数据都可在 https://vertebrate.genenames.org/ 上获得。本文概述了我们的在线数据和资源，重点介绍了过去两年的更新。
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