辅助性T细胞17相关细胞因子在老年哮喘中的作用
Role of Th17-cell related cytokines in geriatric asthma.
作者信息
Quan-San Zhang, Xiaohong Xu, Ying Li, Zhaojia Sun
机构信息
Qingdao Municipal Hospital Group Emergency Department, Qingdao, China.
出版信息
J Int Med Res. 2019 Feb;47(2):580-590. doi: 10.1177/0300060518803828. Epub 2018 Oct 10.
OBJECTIVE
This study aimed to investigate the pathogenesis of geriatric asthma through immunoglobulin E (IgE), interleukin-17A (IL-17A), IL-17F, and glucocorticoid receptor-β (GR-β) expression.
METHODS
We studied 51 geriatric male patients with asthma and 50 young male patients with asthma. We also included 21 normal geriatric males and 21 normal young males. All geriatric and young patients were divided into groups according to pulmonary function. Levels of cytokines, such as IgE, IL-17A, IL-17F, and GR-β, were measured. Pulmonary function was assessed. The results from patients were compared with those from the 42 healthy subjects.
RESULTS
Serum IgE, IL-17A, IL-17F, and GR-β levels in geriatric patients with moderate or severe asthma were significantly higher than those in young patients with moderate asthma and in the normal population. Geriatric patients with asthma had higher asthma control test scores than did young patients with asthma.
CONCLUSION
Hormone resistance in geriatric male patients with asthma is more serious than that in young male patients with asthma. Airway inflammation and airway remodeling in geriatric male patients with asthma may be more serious than those in young male patients with asthma, even when there is similar pulmonary function.
目的
本研究旨在通过免疫球蛋白E（IgE）、白细胞介素-17A（IL-17A）、IL-17F和糖皮质激素受体-β（GR-β）的表达来探讨老年哮喘的发病机制。
方法
我们研究了51例老年男性哮喘患者和50例年轻男性哮喘患者。我们还纳入了21例正常老年男性和21例正常年轻男性。所有老年和年轻患者均根据肺功能分组。检测了细胞因子如IgE、IL-17A、IL-17F和GR-β的水平。评估了肺功能。将患者的结果与42名健康受试者的结果进行比较。
结果
中度或重度老年哮喘患者的血清IgE、IL-17A、IL-17F和GR-β水平显著高于中度年轻哮喘患者和正常人群。老年哮喘患者的哮喘控制测试得分高于年轻哮喘患者。
结论
老年男性哮喘患者的激素抵抗比年轻男性哮喘患者更严重。即使肺功能相似，老年男性哮喘患者的气道炎症和气道重塑可能比年轻男性哮喘患者更严重。
Zotero 插件