Drugan R C, Basile A S, Crawley J N, Paul S M, Skolnick P
Brain Res Bull. 1987 Jan;18(1):143-5. doi: 10.1016/0361-9230(87)90044-x.
"Peripheral" benzodiazepine binding sites (PBS) were studied in both the CNS and peripheral tissues of Maudsley reactive (MR) and Maudsley non-reactive (MNR) rats using the PBS specific ligand [3H]Ro 5-4864. A statistically significant reduction in the density of PBS was found in heart and kidney of the MR compared to the MNR. Similar reductions in the density of PBS were not observed in a number of areas of the central nervous system (including cortex, hippocampus, and hypothalamus) or other peripheral tissues, such as lung and adrenal. This selective decrease in PBS in a strain selectively bred for a high degree of "fearfulness" may be related to previous findings of a reduction in the density of PBS in the same tissues in rats subjected to uncontrollable shock. These observations suggest that PBS in heart and kidney may be altered in response to fear or anxiety.
使用苯二氮䓬类药物外周结合位点（PBS）特异性配体[3H]Ro 5-4864，对莫兹利反应型（MR）和莫兹利非反应型（MNR）大鼠的中枢神经系统和外周组织中的“外周”苯二氮䓬类药物结合位点（PBS）进行了研究。与MNR相比，在MR大鼠的心脏和肾脏中发现PBS密度有统计学意义的降低。在中枢神经系统的多个区域（包括皮质、海马体和下丘脑）或其他外周组织（如肺和肾上腺）中未观察到PBS密度有类似降低。在一个因高度“恐惧”而选择性培育的品系中，PBS的这种选择性降低可能与之前在遭受不可控休克的大鼠相同组织中PBS密度降低的研究结果有关。这些观察结果表明，心脏和肾脏中的PBS可能会因恐惧或焦虑而发生改变。
