Lipson S M
Clin Immunol Immunopathol. 1987 Apr;43(1):65-72. doi: 10.1016/0090-1229(87)90157-7.
Polybrominated biphenyls (PBB) have been shown to affect the immune system of exposed Michigan farm workers and their families. The purpose of this study was to evaluate the effects of PBB on the function and on the synthesis of immunoglobulins by peripheral blood lymphocytes. Concentrations of PBB as low as 0.001 microgram/10(5) cells decreased lymphocyte response to pokeweed mitogen; higher concentrations of PBB stimulated the in vitro synthesis and release of immunoglobulins. PBB had no effect on the quantity of E-rosette-forming cells, the total T or B cells, or the ratio of helper to suppressor T-cell subpopulations. Enhanced release of IgG was identified in lymphocyte cultures obtained from blood specimens of PBB-exposed Michigan farmers. The data from this study suggest that PBB exerted an adverse effect on cell function, but produced a nonspecific activation of B lymphocytes.
多溴联苯（PBB）已被证明会影响密歇根州接触过它的农场工人及其家人的免疫系统。本研究的目的是评估PBB对外周血淋巴细胞功能以及免疫球蛋白合成的影响。低至0.001微克/10⁵个细胞的PBB浓度会降低淋巴细胞对商陆有丝分裂原的反应；更高浓度的PBB会刺激免疫球蛋白的体外合成和释放。PBB对E花环形成细胞的数量、总T细胞或B细胞，或辅助性T细胞亚群与抑制性T细胞亚群的比例均无影响。在从接触过PBB的密歇根州农民血液样本中获得的淋巴细胞培养物中，发现IgG的释放增加。这项研究的数据表明，PBB对细胞功能产生了不利影响，但对B淋巴细胞产生了非特异性激活作用。
