密歇根州和威斯康星州奶农的癌胚抗原（CEA）血浆水平
Carcinoembryonic antigen (CEA) plasma levels in Michigan and Wisconsin dairy farmers.
作者信息
Anderson H A, Rosenman K D, Snyder J
出版信息
Environ Health Perspect. 1978 Apr;23:193-7. doi: 10.1289/ehp.7823193.
Carcionogenic embryonic antigen (CEA) titers were determined for 611 Michigan farmers exposed to PBB and a control nonexposed population of 139 Wisconsin farmers. The overall prevalence of elevated CEA titers was slightly higher in the Michigan study group, but the difference was not statistically significant. Smoking and/or significant past or present conditions (inflammatory bowel disease, ulcers, polyps, liver disease, chronic lung disease, or malignancies) were found to result in higher prevalence of elevated CEA titers, in both the Michigan study group and the Wisconsin control group, thus confirming previous reports. In addition, serum PBB concentrations appeared to be positively correlated with CEA titers. The possibility that the effect of PBB concentrations appeared to be positively correlated with CEA titers. The possibility that the effect of PBB may be additive to that of other factors which are known to result in an increased prevalence of elevated CEA titers is discussed.
对611名接触多溴联苯的密歇根州农民以及139名未接触多溴联苯的威斯康星州农民组成的对照人群测定了癌胚抗原（CEA）滴度。密歇根州研究组中CEA滴度升高的总体患病率略高，但差异无统计学意义。在密歇根州研究组和威斯康星州对照组中，均发现吸烟和/或既往或当前存在的重大疾病（炎症性肠病、溃疡、息肉、肝病、慢性肺病或恶性肿瘤）会导致CEA滴度升高的患病率更高，这证实了先前的报告。此外，血清多溴联苯浓度似乎与CEA滴度呈正相关。讨论了多溴联苯浓度的影响似乎与CEA滴度呈正相关的可能性。还讨论了多溴联苯的影响可能与其他已知会导致CEA滴度升高患病率增加的因素的影响相加的可能性。
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