Wolff M S, Aubrey B
Environ Health Perspect. 1978 Apr;23:211-5. doi: 10.1289/ehp.7823211.
In November, 1976 the Environmental Sciences Laboratory of the Mount Sinai School of Medicine, examined 1029 persons in Michigan for the potential health effects of exposure to PBB. Included in this group were 55 persons from Michigan Chemical Corporation and 237 farming families. Blood serum was analyzed for PBB. FireMaster FF-1 contains several bromobiphenyl components, the major constituent being approximately 60% 2,4,4,2'4'4'-hexabromobiphenyl. Other PBB homologs identifiable as peaks by gas chromatography--mass spectrometry include two pentabromobiphenyl peaks, three additional hexabromobiphenyl peaks, and two heptabromobiphenyl peaks. The relative concentrations, with respect to the major hexabromobiphenyl peak, of these minor constituents (1--20%) of PBB were different for persons from Michigan Chemical Corporation and for farmers. Penta-, hexa-, and hepta-bromobiphenyl components in serum samples analyzed from farming families from Michigan Chemical Corporation employees were compared with relative concentrations of these homologs in FireMaster mixture and in tissue and blood samples from rats fed FireMaster FF-1. Varying concentrations of these PBB components are attributed to different routes of exposure and the relative ease of metabolism and excretion of one pentabromobiphenyl component.
1976年11月，西奈山医学院环境科学实验室对密歇根州的1029人进行了检查，以确定接触多溴联苯对健康的潜在影响。该组人员包括来自密歇根化学公司的55人和237个农户家庭。对血清进行了多溴联苯分析。FireMaster FF - 1含有几种溴代联苯成分，主要成分约为60%的2,4,4,2'4'4'-六溴联苯。通过气相色谱 - 质谱法可识别为峰的其他多溴联苯同系物包括两个五溴联苯峰、另外三个六溴联苯峰和两个七溴联苯峰。密歇根化学公司人员和农户的这些多溴联苯次要成分（1 - 20%）相对于主要六溴联苯峰的相对浓度有所不同。将密歇根化学公司员工农户家庭血清样本中分析的五溴、六溴和七溴联苯成分与FireMaster混合物以及喂食FireMaster FF - 1的大鼠组织和血液样本中这些同系物的相对浓度进行了比较。这些多溴联苯成分的不同浓度归因于不同的接触途径以及一种五溴联苯成分相对容易的代谢和排泄情况。
