Kim Seong-Eun, Tieu My Van, Hwang Sei Young, Lee Min-Ho
Human IT Convergence Research Center, Korea Electronics Technology Institute, Gyeonggi-do 13509, Korea.
School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Seoul 06974, Korea.
Micromachines (Basel). 2020 Mar 13;11(3):302. doi: 10.3390/mi11030302.
The growing interest in magnetic materials as a universal tool has been shown by an increasing number of scientific publications regarding magnetic materials and its various applications. Substantial progress has been recently made on the synthesis of magnetic iron oxide particles in terms of size, chemical composition, and surface chemistry. In addition, surface layers of polymers, silica, biomolecules, etc., on magnetic particles, can be modified to obtain affinity to target molecules. The developed magnetic iron oxide particles have been significantly utilized for diagnostic applications, such as sample preparations and biosensing platforms, leading to the selectivity and sensitivity against target molecules and the ease of use in the sensing systems. For the process of sample preparations, the magnetic particles do assist in target isolation from biological environments, having non-specific molecules and undesired molecules. Moreover, the magnetic particles can be easily applied for various methods of biosensing devices, such as optical, electrochemical, and magnetic phenomena-based methods, and also any methods combined with microfluidic systems. Here we review the utilization of magnetic materials in the isolation/preconcentration of various molecules and cells, and their use in various techniques for diagnostic biosensors that may greatly contribute to future innovation in point-of-care and high-throughput automation systems.
越来越多关于磁性材料及其各种应用的科学出版物表明，人们对将磁性材料作为一种通用工具的兴趣与日俱增。最近在磁性氧化铁颗粒的合成方面，在尺寸、化学成分和表面化学方面取得了重大进展。此外，磁性颗粒上的聚合物、二氧化硅、生物分子等表面层可以进行改性，以获得对目标分子的亲和力。已开发的磁性氧化铁颗粒已被大量用于诊断应用，如样品制备和生物传感平台，从而实现了对目标分子的选择性和灵敏度以及在传感系统中的易用性。对于样品制备过程，磁性颗粒确实有助于从生物环境中分离目标，去除非特异性分子和不需要的分子。此外，磁性颗粒可以很容易地应用于各种生物传感装置的方法，如基于光学、电化学和磁现象的方法，以及任何与微流控系统相结合的方法。在这里，我们综述了磁性材料在各种分子和细胞的分离/预浓缩中的应用，以及它们在各种诊断生物传感器技术中的应用，这些应用可能会极大地推动即时护理和高通量自动化系统的未来创新。
