Department of Obstetrics and Gynecology, LMU Munich, University Hospital, Marchioninistrasse 15, 81377, Munich, Germany.
Klinikum Der Universität München, Pathologisches Institut, Munich, Germany.
Arch Gynecol Obstet. 2019 Jan;299(1):203-209. doi: 10.1007/s00404-018-4928-9. Epub 2018 Oct 10.
Cervical cancer is one of the most frequent cancers in women worldwide. In most of all cases, a persistent HPV infection is the leading cause. HPV-specific sequences are able to bind glucocorticoid receptor (GR). Dexamethasone can increase the activity of early promoters in HPV16 and HPV18 interfering in transcription control of viral oncogenes. The aim of our study was to evaluate glucocorticoid receptor as transcriptional factor in its active form in the nucleus of in cervical cancer cells and to correlate the results with clinical patient specific parameters.
A total of 250 paraffin-embedded cervical cancer samples obtained from patients having undergone surgery for cervical cancer were used for the study. The expression of GR was immunhistochemical examined and evaluated by a semi-quantitative scoring. SPSS software was used for the statistical evaluation of staining results and survival analysis of patients with cervical cancer.
GR is frequently expressed in cervical carcinoma tissue in favor of squamous cell carcinoma (SCC). An enhanced expression is correlated with rather small clinical stages. The expression of the GR is correlated with better overall survival and progression-free survival.
The glucocorticoid receptor is frequently expressed in cervical carcinoma tissue in favor of squamous cell carcinoma. An enhanced expression is correlated with rather small clinical stages. The expression of the analyzed receptor is correlated with better overall survival. Further studies are needed to determine useful treatment targets for glucocorticoid receptor manipulation.
宫颈癌是全球女性最常见的癌症之一。在大多数情况下，持续性 HPV 感染是主要原因。HPV 特异性序列能够结合糖皮质激素受体（GR）。地塞米松可以增加 HPV16 和 HPV18 早期启动子的活性，干扰病毒癌基因的转录控制。我们的研究目的是评估糖皮质激素受体作为转录因子在宫颈癌细胞核中的活性形式，并将结果与临床患者的特定参数相关联。
本研究共使用了 250 例来自接受宫颈癌手术的患者的石蜡包埋宫颈癌样本。通过半定量评分法对 GR 的表达进行免疫组织化学检查和评估。使用 SPSS 软件对宫颈癌患者的染色结果进行统计学评估和生存分析。
GR 在宫颈癌组织中频繁表达，有利于鳞状细胞癌（SCC）。增强的表达与较小的临床分期相关。GR 的表达与更好的总生存率和无进展生存率相关。
糖皮质激素受体在宫颈癌组织中频繁表达，有利于鳞状细胞癌。增强的表达与较小的临床分期相关。分析的受体表达与更好的总生存率相关。需要进一步研究以确定糖皮质激素受体操作的有用治疗靶点。
