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宫颈鳞状细胞癌中肿瘤浸润免疫细胞的预后相关性

Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma.

作者信息

Wild Carl Mathis, Garrido Fabian, Dannecker Christian, Köpke Melitta B, Chateau Marie-Christine, Boissière-Michot Florence, Heidegger Helene H, Vattai Aurelia, Kessler Mirjana, Jeschke Udo, Cavaillès Vincent

机构信息

Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany.

Department of Data Management and Clinical Decision Support, Faculty of Medicine, University of Augsburg, 86159 Augsburg, Germany.

出版信息

Cancers (Basel). 2023 Oct 12;15(20):4952. doi: 10.3390/cancers15204952.

DOI:10.3390/cancers15204952
PMID:37894319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10605287/
Abstract

There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs' infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC.

摘要

关于宫颈癌中肿瘤浸润免疫细胞（TIICs）存在各种各样的研究，但从未有人研究过它们与组织病理学亚型相关的预后价值。因此，本研究的目的是对238例散发性宫颈癌中的TIICs进行定量，并研究其与宫颈癌亚型及患者生存的相关性。与宫颈腺癌（CAC，47例样本）相比，宫颈鳞状细胞癌（CSCC，191例样本）亚组中的TIICs水平显著升高。在CSCC中，TIICs浸润与年龄、国际妇产科联盟（FIGO）分期以及组蛋白修饰H3K4me3呈负相关。此外，在CAC中，它与p16、糖皮质激素受体呈正相关，与MDM2蛋白和H3K4me3呈负相关。有趣的是，免疫浸润是CSCC患者无病生存期（DFS）的独立阳性预后指标，TIICs浸润最强的肿瘤患者DFS更好。总之，本研究对CSCC患者与CAC患者的TIIC水平与预后之间的关系提供了一个有差异的概述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/136a9fc85110/cancers-15-04952-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/b0320479eb3b/cancers-15-04952-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/e12496a14b25/cancers-15-04952-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/2a1e546fd102/cancers-15-04952-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/6cb1cba3337b/cancers-15-04952-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/136a9fc85110/cancers-15-04952-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/b0320479eb3b/cancers-15-04952-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/e12496a14b25/cancers-15-04952-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/2a1e546fd102/cancers-15-04952-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/6cb1cba3337b/cancers-15-04952-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688f/10605287/136a9fc85110/cancers-15-04952-g005.jpg

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