Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran.
Top Curr Chem (Cham). 2018 Oct 11;376(6):40. doi: 10.1007/s41061-018-0218-z.
Use of cyanoacetohydrazides as precursors in reactions leading to construction of heterocycles is reviewed. In addition to some common heterocyclic compounds, synthesis of other uncommon heterocycles such as thiadiazole, oxadiazole, fused heterocycles, and some seven- and eight-membered heterocycles such as benzodiazepine, oxazepine, and benzoxocine starting with cyanoacetohydrazides and their derivatives is also reported. The main aim of this review is to show the application of cyanoacetohydrazides in heterocyclic synthesis via different types of reaction, including cyclocondensation and cyclization. The results are arranged in terms of the type of heterocycle formed, from five-, six-, seven-, to eight-membered and fused rings. This review aims to cover literature up to 2018, showing the distribution of publications involving use of cyanoacetohydrazides for preparation of heterocycles.
本文综述了氰基乙酰胺类作为前体在构建杂环化合物反应中的应用。除了一些常见的杂环化合物外，本文还报道了其他不常见的杂环化合物的合成，如噻二唑、恶二唑、稠合杂环以及一些七元和八元杂环，如苯并二氮杂䓬、噁唑并嗪和苯并噁嗪，它们都是以氰基乙酰胺及其衍生物为起始原料合成的。本文综述的主要目的是展示氰基乙酰胺通过不同类型的反应（包括环缩合和环化）在杂环合成中的应用。根据形成的杂环类型，结果按五、六、七和八元环以及稠合环进行排列。本文综述涵盖了截至 2018 年的文献，展示了涉及氰基乙酰胺用于杂环制备的出版物分布情况。
