Mansorian Behnam, Mirza-Aghazadeh Attari Mohammad, Vahabzadeh Davoud, Mohebbi Iraj
Nutr Hosp. 2018 Oct 5;35(5):1107-1114. doi: 10.20960/nh.1719.
the sedentary lifestyle is related to the incidence of various diseases and metabolic disorders. The aim of the current study was to understand the link between serum vitamin D levels, thyroid hormones and lipid profiles among Iranian sedentary staff.
in this cross-sectional study, 300 healthy subjects with normal body mass index (BMI) and age between 18 and 65 years, with sedentary lifestyles, were included. Serum levels of 25-hydroxyvitamin D, thyroid stimulating hormone (TSH), fasting blood sugar, plasma total cholesterol, and high-density lipoprotein (HDL) and triglycerides (TG) were measured with qualified laboratory methods. Low-density lipoprotein (LDL) concentration was calculated based on the Friedewald equation. A self-made questionnaire with different questions was used to assess physical activity.
the means of BMI and age were 25.63 ± 10.25 and 36.69 ± 7.14 years, respectively. The prevalence of vitamin D deficiency was 65.7%. Results showed significant differences for TG, HDL, and thyroxine (T4) between subgroup categories. Serum levels of 25-hydroxyvitamin D had a negative significant correlation with triiodothyronine (T3) and T4, and a positive correlation with HDL. Linear regression analysis showed a significant association of 25-hydroxyvitamin D concentrations with HDL and T4 after adjustments based on the sex.
finally, the results of this study show that with the improvement in vitamin D status, the decrease in the levels of TG, T3 and T4, with an increase in HDL can be expected. So, verification and detection of true causality through the interventional studies will be valuable, scientifically.
久坐不动的生活方式与多种疾病和代谢紊乱的发生率相关。本研究的目的是了解伊朗久坐办公人员血清维生素D水平、甲状腺激素和血脂谱之间的联系。
在这项横断面研究中，纳入了300名体重指数（BMI）正常、年龄在18至65岁之间且生活方式久坐的健康受试者。采用合格的实验室方法测量血清25-羟维生素D、促甲状腺激素（TSH）、空腹血糖、血浆总胆固醇、高密度脂蛋白（HDL）和甘油三酯（TG）水平。低密度脂蛋白（LDL）浓度根据Friedewald方程计算。使用一份包含不同问题的自制问卷来评估身体活动情况。
BMI和年龄的平均值分别为25.63±10.25和36.69±7.14岁。维生素D缺乏的患病率为65.7%。结果显示，亚组类别之间的TG、HDL和甲状腺素（T4）存在显著差异。血清25-羟维生素D水平与三碘甲状腺原氨酸（T3）和T4呈显著负相关，与HDL呈正相关。线性回归分析显示，在根据性别进行调整后，25-羟维生素D浓度与HDL和T4之间存在显著关联。
最后，本研究结果表明，随着维生素D状况的改善，预计TG、T3和T4水平会降低，HDL会升高。因此，通过干预性研究验证和检测真正的因果关系在科学上具有重要价值。
