Matos Andrea, Gonçalves Vanessa Moreira da Silveira, Souza Gisele, Cruz Suelem Pereira da, Cruz Sabrina, Ramalho Andréa
Universidade Federal do Rio de Janeiro.
Nutr Hosp. 2018 Oct 8;35(5):1215-1220. doi: 10.20960/nh.1804.
the purpose of this study was to assess the vitamin A (VA) nutritional status of patients with coronary artery disease (CAD) and its correlation with the severity of the disease, taking into consideration zinc concentration and oxidative stress.
the patients were preoperative inpatients awaiting myocardial revascularization surgery. The serum concentrations of retinol, β-carotene, zinc, malondialdehyde (MDA) and C-reactive protein (CRP) were quantified. CAD severity was assessed by cineangiography, observing the parameters of severity, extent and occlusion. An echocardiogram was performed to assess the ejection fraction.
ninety individuals were studied (64.5 ± 9.6 years). Zinc did not correlate with retinol (r = -0.009/p = 0.40), β-carotene (r = -0.06/p = 0.73) or MDA (r = 0.03/p = 0.70), but zinc deficiency was more frequent amongst the patients with high MDA (quartiles 50 and 75). CRP was found to be associated with retinol (x2 = 3.95/p = 0.04). The individuals with retinol deficiency had more severe CAD, and β-carotene diminished as the extent score rose, although this was not statistically significant (p = 0.12). The degree of severity was associated to extent (x2 = 67.9)/(p < 0.001), occlusion (x2 = 34.5/p < 0.001) and CRP (x2 = 5.9/p = 0.05), while extent was associated with MDA (x2 = 42.1)/(p < 0.001). There was a positive correlation between the ejection fraction and β-carotene (r = 0.42/p = 0.02).
findings from this study indicate that chronic inflammation resulting from atherosclerosis is related to disease severity and consequent influence on nutritional status of VA.
本研究旨在评估冠状动脉疾病（CAD）患者的维生素A（VA）营养状况及其与疾病严重程度的相关性，并考虑锌浓度和氧化应激因素。
研究对象为等待心肌血运重建手术的术前住院患者。对血清视黄醇、β-胡萝卜素、锌、丙二醛（MDA）和C反应蛋白（CRP）的浓度进行定量分析。通过血管造影评估CAD的严重程度，观察严重程度、范围和闭塞参数。进行超声心动图检查以评估射血分数。
共研究了90名个体（64.5±9.6岁）。锌与视黄醇（r = -0.009/p = 0.40）、β-胡萝卜素（r = -0.06/p = 0.73）或MDA（r = 0.03/p = 0.70）均无相关性，但在MDA水平较高（四分位数50和75）的患者中锌缺乏更为常见。发现CRP与视黄醇相关（x2 = 3.95/p = 0.04）。视黄醇缺乏的个体CAD更为严重，且随着范围评分升高β-胡萝卜素水平降低，尽管这在统计学上无显著意义（p = 0.12）。严重程度与范围（x2 = 67.9）/（p < 0.001）、闭塞（x2 = 34.5/p < 0.001）和CRP（x2 = 5.9/p = 0.05）相关，而范围与MDA相关（x2 = 42.1）/（p < 0.001）。射血分数与β-胡萝卜素呈正相关（r = 0.42/p = 0.02）。
本研究结果表明，动脉粥样硬化引起的慢性炎症与疾病严重程度相关，并进而影响VA的营养状况。
