Clinical Microbiology Laboratory, Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA.
Clinical Microbiology Laboratory, Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA; Massachsuetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cell Host Microbe. 2018 Oct 10;24(4):470-471. doi: 10.1016/j.chom.2018.09.014.
Microbial activities of gut commensals have been linked to several host diseases. In recent work, Roberts et al. (2018) develop therapeutics targeting microbial production of the metabolite trimethylamine (TMA), which has been linked to cardiovascular disease. This microbiota-based approach holds promise for efficacious therapies that may also reduce host side effects.
肠道共生菌的微生物活性与多种宿主疾病有关。在最近的工作中，Roberts 等人（2018 年）开发了针对微生物产生代谢物三甲胺（TMA）的治疗方法，TMA 与心血管疾病有关。这种基于微生物组的方法有望开发出有效的治疗方法，同时也可能减少宿主的副作用。
