López-Verdín Sandra, Lavalle-Carrasco Jesús, Carreón-Burciaga Ramón G, Serafín-Higuera Nicolás, Molina-Frechero Nelly, González-González Rogelio, Bologna-Molina Ronell
Research Institute of Dentistry, Health Science Center, Universidad de Guadalajara, Guadalajara 4430, JAL, Mexico.
Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango, Durango 34000, DGO, Mexico.
Cancers (Basel). 2018 Oct 10;10(10):376. doi: 10.3390/cancers10100376.
This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell carcinoma, physicians face yet another challenge-that of preserving oral functions, which involves the use of multidisciplinary therapies, such as multiple chemotherapies (CT) and radiotherapy (RT). Designing personalized therapeutic options requires the study of genes involved in drug resistance. This review provides an overview of the molecules that have been linked to resistance to chemotherapy in HNSCC, including the family of ATP-binding cassette transporters (ABCs), nucleotide excision repair/base excision repair (NER/BER) enzymatic complexes (which act on nonspecific DNA lesions generated by gamma and ultraviolet radiation by cross-linking and forming intra/interchain chemical adducts), cisplatin (a chemotherapeutic agent that causes DNA damage and induces apoptosis, which is a paradox because its effectiveness is based on the integrity of the genes involved in apoptotic signaling pathways), and cetuximab, including a discussion of the genes involved in the cell cycle and the proliferation of possible markers that confer resistance to cetuximab.
本手稿提供了关于在头颈部鳞状细胞癌（HNSCC）的肿瘤耐药治疗中发挥作用的分子的文献更新。尽管头颈部鳞状细胞癌的治疗已取得显著进展，但医生面临着另一个挑战——即保留口腔功能，这涉及到多学科治疗的应用，如多种化疗（CT）和放疗（RT）。设计个性化治疗方案需要研究与耐药相关的基因。本综述概述了与HNSCC化疗耐药相关的分子，包括ATP结合盒转运蛋白（ABC）家族、核苷酸切除修复/碱基切除修复（NER/BER）酶复合物（通过交联和形成链内/链间化学加合物作用于由γ射线和紫外线辐射产生的非特异性DNA损伤）、顺铂（一种导致DNA损伤并诱导凋亡的化疗药物，这是一个悖论，因为其有效性基于凋亡信号通路中相关基因的完整性）和西妥昔单抗，包括对参与细胞周期的基因以及可能赋予西妥昔单抗耐药性的增殖标志物的讨论。
