Instituto de Investigación, Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, Madrid, Spain.
CIBER-Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain.
Eur Respir J. 2018 Dec 6;52(6). doi: 10.1183/13993003.01448-2018. Print 2018 Dec.
There is increasing interest in the origins of chronic obstructive pulmonary disease (COPD), as it is envisaged that preventive efforts and treatment can modify its clinical course. The concept of early COPD is not new, but it has recently regained interest, given new population data, recent cellular and molecular advances and insights from clinical trials. To date, many knowledge gaps in the nature of early COPD still exist, mainly because COPD has always been considered a disease of the elderly, and little attention has been paid to the pathological changes occurring in the lungs of individuals at risk before they develop clinically evident COPD. Future studies should focus on identifying early pathological manifestations of COPD in order to prevent its progression in susceptible individuals. In this review, we aim to summarise what is known on early COPD, from the epidemiological, cellular and clinical perspectives.
人们对慢性阻塞性肺疾病（COPD）的起源越来越感兴趣，因为人们认为预防措施和治疗可以改变其临床过程。早期 COPD 的概念并不新鲜，但由于新的人群数据、最近的细胞和分子进展以及临床试验的结果，最近它又重新引起了人们的兴趣。迄今为止，早期 COPD 的性质仍然存在许多知识空白，主要是因为 COPD 一直被认为是老年人的疾病，而很少关注在临床明显 COPD 发生之前，处于危险中的个体肺部发生的病理变化。未来的研究应侧重于识别 COPD 的早期病理表现，以防止其在易感个体中进展。在这篇综述中，我们旨在从流行病学、细胞和临床角度总结人们对早期 COPD 的了解。
