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氟喹诺酮类抗生素对兽医和人畜共患病重要的血液寄生虫 和 的抑制作用。

Inhibitory effects of fluoroquinolone antibiotics on and , blood parasites of veterinary and zoonotic importance.

作者信息

Rizk Mohamed Abdo, AbouLaila Mahmoud, El-Sayed Shimaa Abd El-Salam, Guswanto Azirwan, Yokoyama Naoaki, Igarashi Ikuo

机构信息

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan,

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.

出版信息

Infect Drug Resist. 2018 Sep 28;11:1605-1615. doi: 10.2147/IDR.S159519. eCollection 2018.

DOI:10.2147/IDR.S159519
PMID:30310296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6166754/
Abstract

AIM

This study aimed to evaluate the inhibitory effects of fluoroquinolone antibiotics, including enrofloxacin, enoxacin, trovafloxacin, norfloxacin, and ofloxacin, on the in vitro and in vivo growth of and parasites, respectively.

MATERIALS AND METHODS

The in vitro and in vivo inhibitory effects of fluoroquinolone antibiotics against and , respectively were evaluated using fluorescence-based assay. Additionally, combination therapies of highly effective fluoroquinolone antibiotics (enrofloxacin, enoxacin, and trovafloxacin) with diminazene aceturate, luteolin, or pyronaridine tetraphosphate were tested on the in vitro cultures of .

RESULTS

Enrofloxacin, trovafloxacin, and enoxacin were the most effective fluoroquinolones against the in vitro growth of , followed by norfloxacin and ofloxacin. Furthermore, a combination of enoxacin or trovafloxacin with either diminazene aceturate, luteolin, or pyronaridine tetraphosphate significantly enhanced the inhibitory effect on the growth of in in vitro cultures. In mice infected by , enoxacin and diminazene aceturate combination therapy exhibited a potential antibabesial effect.

CONCLUSION

These results suggest that safe and cheap fluoroquinolone, such as enoxacin, might be used for the treatment of clinical cases caused by spp. in animals or humans.

摘要

目的

本研究旨在分别评估氟喹诺酮类抗生素，包括恩诺沙星、依诺沙星、曲伐沙星、诺氟沙星和氧氟沙星，对体外和体内[寄生虫名称未给出]和[寄生虫名称未给出]寄生虫生长的抑制作用。

材料与方法

使用基于荧光的检测方法分别评估氟喹诺酮类抗生素对体外和体内[寄生虫名称未给出]和[寄生虫名称未给出]的抑制作用。此外，还测试了高效氟喹诺酮类抗生素（恩诺沙星、依诺沙星和曲伐沙星）与乙酰马杜霉素、木犀草素或磷酸咯萘啶的联合疗法对[寄生虫名称未给出]体外培养物的效果。

结果

恩诺沙星、曲伐沙星和依诺沙星是对[寄生虫名称未给出]体外生长最有效的氟喹诺酮类药物，其次是诺氟沙星和氧氟沙星。此外，依诺沙星或曲伐沙星与乙酰马杜霉素、木犀草素或磷酸咯萘啶的组合显著增强了对体外培养物中[寄生虫名称未给出]生长的抑制作用。在感染[寄生虫名称未给出]的小鼠中，依诺沙星和乙酰马杜霉素联合疗法显示出潜在的抗巴贝斯虫作用。

结论

这些结果表明，安全且廉价的氟喹诺酮类药物，如依诺沙星，可用于治疗动物或人类由[寄生虫名称未给出]属引起的临床病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/e735c950f72f/idr-11-1605Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/d7cc5640dcfc/idr-11-1605Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/2d19b5268ae3/idr-11-1605Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/189fb2d92836/idr-11-1605Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/1b36d93b1cd0/idr-11-1605Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/82cc36f8eb6c/idr-11-1605Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/e735c950f72f/idr-11-1605Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/d7cc5640dcfc/idr-11-1605Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/2d19b5268ae3/idr-11-1605Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/189fb2d92836/idr-11-1605Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/1b36d93b1cd0/idr-11-1605Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/82cc36f8eb6c/idr-11-1605Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7512/6166754/e735c950f72f/idr-11-1605Fig6.jpg

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