Smith G L, Goulbourn R A, Burt R A, Chatfield D H
Br J Clin Pharmacol. 1977 Oct;4(5):585-90. doi: 10.1111/j.1365-2125.1977.tb00790.x.
1 Benoxaprofen is a new acidic anti-inflammatory compound which was well absorbed after oral administration to man. 2 Single doses of 100, 200 and 400 mg produced mean peak concentrations in the plasma of 13.0, 33.5 and 45.3 microgram respectively, and the plasma half-life of the compound was between 30 and 35 hours. 3 Multiple dosing with 25 and 50 mg every 24 h achieved an equilibrium conentration in the plasma after 6-8 days, while dosing with 100 mg every 12 h enabled equilibrium to be reached in 3-6 days. Plasma concentrations between 35 and 45 microgram/ml were achieved by giving 100 mg doses every 12 hours. 4 Absorption of benoxaprofen was delayed when the drug was given with food, but the total amount absorbed remained the same. 5 The effect of milling the material to small particle size (19 micron) was to increase the rate of absorption compared to that of unmilled material (58 micron). 6 Benoxaprofen was well tolerated by healthy male subject in the doses given.
苯恶洛芬是一种新型酸性抗炎化合物，人体口服后吸收良好。
单次服用100毫克、200毫克和400毫克时，血浆中的平均峰值浓度分别为13.0微克、33.5微克和45.3微克，该化合物的血浆半衰期在30至35小时之间。
每24小时服用25毫克和50毫克，多次给药6至8天后血浆中达到平衡浓度；每12小时服用100毫克，3至6天可达到平衡。每12小时服用100毫克剂量可使血浆浓度达到35至45微克/毫升。
苯恶洛芬与食物同服时吸收延迟，但吸收总量不变。
将材料研磨成小颗粒（19微米）后，与未研磨材料（58微米）相比，吸收速率增加。
健康男性受试者对所给剂量的苯恶洛芬耐受性良好。
