Woodhouse K W, Wynne H
Clin Pharmacokinet. 1987 Feb;12(2):111-22. doi: 10.2165/00003088-198712020-00002.
The elderly often suffer from chronic musculoskeletal disease, and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to control symptoms. The aged have been shown to be particularly at risk of adverse effects from these drugs, of which gastrointestinal irritation and bleeding are both common and potentially serious. Because of this, a comparison of NSAID pharmacokinetics in young and elderly subjects is of particular importance. In general, protein binding tends to decrease with age; volumes of distribution may undergo a small increase; and clearance, especially of renally eliminated drugs, may fall. However, these changes are relatively minor, and the increased propensity of the elderly to suffer adverse reactions to NSAIDs cannot readily be explained on a pharmacokinetic basis.
老年人常患慢性肌肉骨骼疾病，非甾体抗炎药（NSAIDs）被广泛用于控制症状。已表明老年人尤其易受这些药物不良反应的影响，其中胃肠道刺激和出血既常见又可能很严重。因此，比较年轻和老年受试者中NSAIDs的药代动力学尤为重要。一般来说，蛋白质结合率往往会随着年龄增长而降低；分布容积可能会略有增加；清除率，尤其是经肾脏排泄药物的清除率，可能会下降。然而，这些变化相对较小，老年人对NSAIDs不良反应增加的倾向不能轻易从药代动力学角度来解释。
