Department of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry, University of California, Los Angeles 90095, USA.
Nat Prod Rep. 2019 May 22;36(5):698-713. doi: 10.1039/c8np00075a.
Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review.
2000 年至 2018 年 周环反应是一类具有广泛合成用途的独特反应。在本综述中描述的最近的发现之前,酶催化的周环反应尚未被广泛认为参与生物合成。这种情况正在迅速改变。我们定义了周环反应的范围,追溯了它们作为生物合成反应的发现历史,并提供了证据表明自然界中有许多酶可以催化周环反应。这些酶,即“周环酶”,是本综述的主题。