Khanal Sagar, Khan Seraj Ahmed, Baral Dharnidhar, Shrestha Sanjeeb, Baral Nirmal, Lamsal Madhab
Department of Biochemistry, Lumbini Medical College, Palpa, Nepal.
Department of Biochemistry, BPKIHS, Dharan, Nepal.
BMC Res Notes. 2018 Oct 12;11(1):727. doi: 10.1186/s13104-018-3832-5.
Pan Masala containing Tobacco (PMT) use contributes significantly to the overall world tobacco burden especially in south Asian country like Nepal. Oxidative stress caused by it may leads to cardiovascular disease, peripheral vascular disease, hypertension, etc. Therefore, this work proposes to study the antioxidant and oxidative stress along with cardiovascular morbidity in PMT users.
Hundred PMT users and 80 non-user controls with age and sex matched were enrolled. There was a significant difference in blood pressure, albumin, uric acid, vitamin C, vitamin E, malondialdehyde (MDA), total cholesterol, triglycerides, low density lipoprotein cholesterol between the two groups (p < 0.001). We observed statistically significant (p < 0.001) decrease in antioxidant and increase oxidative stress in PMT users. Duration and quantity of PMT user were significantly associated with the MDA level.
含烟草的嚼烟（PMT）的使用对全球烟草总负担有显著影响，尤其是在尼泊尔等南亚国家。其引起的氧化应激可能导致心血管疾病、外周血管疾病、高血压等。因此，本研究旨在探讨PMT使用者的抗氧化和氧化应激情况以及心血管发病率。
招募了100名年龄和性别匹配的PMT使用者和80名非使用者作为对照。两组之间的血压、白蛋白、尿酸、维生素C、维生素E、丙二醛（MDA）、总胆固醇、甘油三酯、低密度脂蛋白胆固醇存在显著差异（p < 0.001）。我们观察到PMT使用者的抗氧化剂水平在统计学上显著降低（p < 0.001），氧化应激增加。PMT使用者的使用时长和使用量与MDA水平显著相关。
