Citrus Research Institute, Southwest University, Chongqing, 400715, China.
Citrus Research Institute, Southwest University, Chongqing, 400715, China.
Biochem Biophys Res Commun. 2018 Nov 10;505(4):991-995. doi: 10.1016/j.bbrc.2018.10.035. Epub 2018 Oct 9.
Obesity is associated with the changes in gut microbiota. The aim of present study was to investigate the effects of sweet orange essential oil (SOEO) microcapsules on body weight and gut microbiota in obese rats induced by high-fat diet. By analyzing the body weight, fat rate and the sequence of cloned microbial small-subunit ribosomal RNA genes (16S rDNA) in rats fecal samples, we found that SOEO microcapsules decreased the body weight and increased the relative abundance of Bifidobacterium (genus-level) in gut microbiota. The analysis of endotoxin content proved that SOEO microcapsules protected gut barrier and decreased gut endotoxin levels by increasing the content of Bifidobacterium, then ameliorated low-grade inflammation, achieving the goal of losing weight. This might be the mechanism of SOEO microcapsules to lose body weight and provided a novel anti-obesity dietary supplement.
肥胖与肠道微生物群的变化有关。本研究旨在探讨甜橙精油（SOEO）微胶囊对高脂肪饮食诱导肥胖大鼠体重和肠道微生物群的影响。通过分析大鼠粪便样本中的体重、脂肪率和克隆微生物小亚基核糖体 RNA 基因（16S rDNA）序列，我们发现 SOEO 微胶囊降低了体重，增加了肠道微生物群中双歧杆菌（属水平）的相对丰度。内毒素含量分析证明，SOEO 微胶囊通过增加双歧杆菌的含量来保护肠道屏障，降低肠道内毒素水平，从而改善低度炎症，达到减肥的目的。这可能是 SOEO 微胶囊减肥的机制，并为新型抗肥胖膳食补充剂提供了依据。
