Wiśniewski Karol, Jóźwik-Pruska Jagoda, Bieńkowski Michał, Bobeff Ernest J, Bryl Maciej, Kałużna-Czaplińska Joanna, Jaskólski Dariusz J
Department of Neurosurgery and Neurooncology, Medical University of Lodz, Barlicki University Hospital, Kopcińskiego 22, 90-153 Lodz, Poland.
Institute of General and Ecological Chemistry, Department of Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924 Lodz, Poland.
Neurol Neurochir Pol. 2018 Nov-Dec;52(6):643-651. doi: 10.1016/j.pjnns.2018.09.009. Epub 2018 Oct 4.
Despite enormous progress in medicine, symptomatic cerebral vasospasm (CVS), remains an unexplained clinical problem, which leaves both physicians and patients helpless and relying on chance, due to the lack of specific marker indicative of imminent danger as well as the lack of specific treatment. In our opinion CVS occurrence depends on dynamic disbalance between free radicals' formation (oxidative stress) and antioxidant activity. Isoprostanes are products of free-radical peroxidation of polyunsaturated fatty acids, and seem to mark a promising path for the research aiming to unravel its possible mechanism. Not only are they the biomarkers of oxidative stress in vivo and in vitro, but also have manifold biological effects (including vasoactive, inflammatory and mitogenic) via activation of the thromboxane A2 receptor (TBXA2R), both in physiological and pathophysiological processes. This review addresses the importance of isoprostanes in CVS in quest of appropriate biomarkers.
尽管医学取得了巨大进步，但症状性脑血管痉挛（CVS）仍然是一个无法解释的临床问题，由于缺乏指示即将发生危险的特异性标志物以及缺乏特异性治疗方法，这使得医生和患者都感到无助，只能寄希望于运气。我们认为，CVS的发生取决于自由基形成（氧化应激）与抗氧化活性之间的动态失衡。异前列腺素是多不饱和脂肪酸自由基过氧化的产物，似乎为旨在揭示其可能机制的研究指明了一条有前景的道路。它们不仅是体内和体外氧化应激的生物标志物，而且在生理和病理生理过程中，通过激活血栓素A2受体（TBXA2R）具有多种生物学效应（包括血管活性、炎症和促有丝分裂）。这篇综述探讨了异前列腺素在CVS中对于寻找合适生物标志物的重要性。
