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评估 IgMi 小鼠作为研究 B 细胞生物学的新型工具。

Evaluating the IgMi mouse as a novel tool to study B-cell biology.

机构信息

Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science centre, The University of Manchester, Manchester, United Kingdom of Great Britain and Northern Ireland.

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

出版信息

Eur J Immunol. 2018 Dec;48(12):2068-2071. doi: 10.1002/eji.201847735. Epub 2018 Oct 26.

DOI:10.1002/eji.201847735
PMID:30315705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6750126/
Abstract

The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and T cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

摘要

IgMi 小鼠不能分泌抗体或从 IgM 类别转换其 BCR。我们的研究表明，IgMi 小鼠的其他细胞区室，包括 B 细胞亚群、DC 亚群、GC B 细胞和 T 细胞，都受到了干扰，因此在使用小鼠来探索分泌抗体的作用时，需要考虑到这些重要的额外因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/378a/6750126/af8036536548/EJI-48-2068-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/378a/6750126/39082051e934/EJI-48-2068-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/378a/6750126/af8036536548/EJI-48-2068-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/378a/6750126/39082051e934/EJI-48-2068-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/378a/6750126/af8036536548/EJI-48-2068-g002.jpg

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