Waisman Ari, Croxford Andrew L, Demircik Filiz
1st Medical Department, University of Mainz, Obere-Zahlbacherstr. 63, 55131 Mainz, Germany.
Med Microbiol Immunol. 2008 Jun;197(2):145-9. doi: 10.1007/s00430-008-0088-z. Epub 2008 Mar 11.
B cells were previously shown to mediate partial protection against CMV infection, as in the absence of B cells, latently infected mice were more susceptible to virus reactivation. It remains unclear if this effect stems from the loss of B cells as antibody producers or as antigen presenting cells. To address this fundamental question, we propose to make use of new mouse models that allow conditional ablation of B cells or that allow for the generation of mice with B cells that are not able to produce antibodies.
先前的研究表明，B细胞可介导对巨细胞病毒（CMV）感染的部分保护作用，因为在缺乏B细胞的情况下，潜伏感染的小鼠更容易发生病毒再激活。目前尚不清楚这种效应是源于作为抗体产生细胞的B细胞缺失，还是作为抗原呈递细胞的B细胞缺失。为了解决这个基本问题，我们建议利用新的小鼠模型，这些模型能够有条件地清除B细胞，或者能够培育出不能产生抗体的B细胞小鼠。
