炎症信号在心房颤动中的作用。
Role of inflammatory signaling in atrial fibrillation.
机构信息
Department of Medicine (Section of Cardiovascular Research), Baylor College of Medicine, Houston, TX, USA; Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, USA.
Department of Medicine (Section of Cardiovascular Research), Baylor College of Medicine, Houston, TX, USA; Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, USA; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.
出版信息
Int J Cardiol. 2019 Jul 15;287:195-200. doi: 10.1016/j.ijcard.2018.10.020. Epub 2018 Oct 4.
Abstract
Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced inflammatory response. Emerging evidence points to a causal role of inflammatory signaling pathways in the evolution of atrial electrical, calcium handling and structural remodeling, which create the substrate of AF development. In this review, we discuss the clinical evidence supporting the association between inflammatory indices and AF development, the molecular and cellular mechanisms of AF, which appear to involve multiple canonical inflammatory pathways, and the potential of anti-inflammatory therapeutic approaches in AF prevention/treatment.
摘要
心房颤动（AF）是最常见的心律失常，常伴有增强的炎症反应。新出现的证据表明炎症信号通路在心房电活动、钙处理和结构重塑的演变中起因果作用，这些改变为 AF 的发展创造了基质。在这篇综述中，我们讨论了支持炎症指标与 AF 发展之间关联的临床证据、AF 的分子和细胞机制，这些机制似乎涉及多种经典炎症途径，以及抗炎治疗方法在 AF 预防/治疗中的潜在应用。
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