Yasukawa Motoaki, Uchiyama Tomoko, Ohbayashi Chiho, Kawaguchi Takeshi, Kawai Norikazu, Sawabata Noriyoshi, Taniguchi Shigeki
Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan.
Department of Diagnostic Pathology, Nara Medical University School of Medicine, Kashihara, Nara, Japan.
Oxf Med Case Reports. 2018 Oct 9;2018(11):omy080. doi: 10.1093/omcr/omy080. eCollection 2018 Nov.
A mediastinal Müllerian cyst is composed of heterotopic cystic Müllerian tissue resembling structures of the fallopian tube. We herein report a case of a mediastinal Müllerian cyst discovered during a medical check-up of a 41-year-old woman. She had no symptoms but had been diagnosed with hyperprolactinemia at the age of 24 years, for which she received hormonal therapy for 3 years. Chest computed tomography demonstrated a 3-cm-diameter cystic tumor in front of the Th10 vertebra. Thoracic surgery was performed to remove the tumor. The tumor was a monolocular cyst covered with a thin capsule, and pathological examination showed a thin-walled cyst lined by ciliated or non-ciliated columnar cells resembling tubal epithelium. Immunohistochemical analysis showed positive expression for paired box gene 8 and estrogen and progesterone receptors. The pathological diagnosis was a Müllerian cyst. A Müllerian cyst should be always be considered in patients with a mediastinal cyst.
纵隔苗勒管囊肿由异位的囊性苗勒管组织构成，类似于输卵管结构。我们在此报告一例在一名41岁女性体检期间发现的纵隔苗勒管囊肿病例。她没有症状，但在24岁时被诊断为高催乳素血症，为此接受了3年的激素治疗。胸部计算机断层扫描显示在第10胸椎前方有一个直径3厘米的囊性肿瘤。进行了胸外科手术切除肿瘤。肿瘤为单房囊肿，被一层薄包膜覆盖，病理检查显示为薄壁囊肿，内衬类似于输卵管上皮的纤毛或无纤毛柱状细胞。免疫组织化学分析显示配对盒基因8以及雌激素和孕激素受体呈阳性表达。病理诊断为苗勒管囊肿。纵隔囊肿患者应始终考虑苗勒管囊肿的可能。
