College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
Biomed Res Int. 2018 Sep 18;2018:5314320. doi: 10.1155/2018/5314320. eCollection 2018.
Fort. ex Lindl. is a plant belonging to the Taxaceae family and cv. Merrillii is the only grafted and thoroughbred species belonging to this species. In this study, we extracted five different seed oils, including seed oil (TGSO), "Xiangyafei" seed oil (XYSO), "Zhimafei" seed oil (ZMSO), "Majus"seed oil (TGMSO), and "cunguangfei" seed oil (CGSO) using physical pressure. The resulting extracts were analyzed to determine their fatty acid composition, antioxidant activity, and inhibitory activity towards tyrosinase. The results of the antioxidant activity assays revealed that XYSO and ZMSO exhibited much greater DPPH radical scavenging activity and ferric reducing power than TGSO. Notably, all five of the seed oils showed dose-dependent inhibitory activity towards tyrosinase. XYSO and TGSO gave the highest activities of all of the seed oils tested in the current study against monophenolase and diphenolase, with IC values of 227.0 and 817.5g/mL, respectively. The results of this study show that wild TGSOs exhibit strong antioxidant and tyrosinase inhibition activities. These results therefore suggest that wild TGSOs could be used as a potential source of natural antioxidant agents and tyrosinase inhibitors.
Fort. ex Lindl. 是 Taxaceae 科的一种植物，而 cv. Merrillii 是该种唯一的嫁接和纯种物种。在本研究中，我们使用物理压力提取了五种不同的种子油，包括 种子油（TGSO）、“香芽飞”种子油（XYSO）、“脂麻飞”种子油（ZMSO）、“大木”种子油（TGMSO）和“葱光飞”种子油（CGSO）。对所得提取物进行了分析，以确定其脂肪酸组成、抗氧化活性和对酪氨酸酶的抑制活性。抗氧化活性测定结果表明，XYSO 和 ZMSO 对 DPPH 自由基的清除活性和铁还原能力均明显强于 TGSO。值得注意的是，五种种子油均对酪氨酸酶表现出剂量依赖性抑制活性。在本研究中，XYSO 和 TGSO 对单酚酶和二酚酶的活性最高，IC 值分别为 227.0 和 817.5g/mL。本研究结果表明，野生 TGSOs 表现出较强的抗氧化和酪氨酸酶抑制活性。因此，这些结果表明野生 TGSOs 可作为天然抗氧化剂和酪氨酸酶抑制剂的潜在来源。
