Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque.
Department of Epidemiology, University of Washington, Seattle.
J Infect Dis. 2019 Feb 23;219(6):908-915. doi: 10.1093/infdis/jiy600.
High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence.
Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes.
The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. hrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years.
HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.
高危型人乳头瘤病毒（hrHPV）可引发宫颈癌。在美国，约有 40%的 14-59 岁女性无论种族和民族都感染了 HPV，且 HPV 感染率通常会随年龄增长而下降。然而，由于对美洲印第安人（AI）女性的采样不足，无法对该人群 HPV 感染率进行特定的人群估计。
从大平原地区一个部落社区中招募了 698 名 21-65 岁的 AI 女性，由她们自行采集阴道拭子。我们估计了该人群中 hrHPV 的流行率，并确定了主要的基因型。
HPV-16、18、31、33、35、39、45、51、52、56、58、59、66 和 68 型 hrHPV 的合并流行率为 34.8%。HPV-51（7.6%）、HPV-58（5.3%）、HPV-52（4.3%）、HPV-18（4.3%）和 HPV-16（3.9%）最为常见。HPV 感染率随年龄下降，21-24 岁女性为 42.2%，50-65 岁女性为 27.9%。
HPV-51 是最常见的致癌基因型。我们样本中 AI 女性的 hrHPV 合并流行率较高，50-65 岁女性尤其如此，该年龄组的 hrHPV 流行率大约是其他种族的三倍。应当加强宫颈癌筛查力度，尤其是针对社区中 30 岁及以上的女性。
