TAM受体在自身免疫性疾病和癌症中的双重作用：综述
The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An Overview.
作者信息
Wium Martha, Paccez Juliano D, Zerbini Luiz F
机构信息
Cancer Genomics Group, International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, South Africa.
Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia 74690-900, GO, Brazil.
出版信息
Cells. 2018 Oct 12;7(10):166. doi: 10.3390/cells7100166.
Receptor tyrosine kinases (RTKs) regulate cellular processes by converting signals from the extracellular environment to the cytoplasm and nucleus. Tyro3, Axl, and Mer (TAM) receptors form an RTK family that plays an intricate role in tissue maintenance, phagocytosis, and inflammation as well as cell proliferation, survival, migration, and development. Defects in TAM signaling are associated with numerous autoimmune diseases and different types of cancers. Here, we review the structure of TAM receptors, their ligands, and their biological functions. We discuss the role of TAM receptors and soluble circulating TAM receptors in the autoimmune diseases systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Lastly, we discuss the effect of TAM receptor deregulation in cancer and explore the therapeutic potential of TAM receptors in the treatment of diseases.
受体酪氨酸激酶（RTK）通过将细胞外环境的信号转换至细胞质和细胞核来调节细胞过程。Tyro3、Axl和Mer（TAM）受体构成一个RTK家族，该家族在组织维持、吞噬作用、炎症以及细胞增殖、存活、迁移和发育中发挥着复杂的作用。TAM信号传导缺陷与多种自身免疫性疾病和不同类型的癌症相关。在此，我们综述TAM受体的结构、其配体及其生物学功能。我们讨论TAM受体和可溶性循环TAM受体在自身免疫性疾病系统性红斑狼疮（SLE）和多发性硬化症（MS）中的作用。最后，我们讨论TAM受体失调在癌症中的影响，并探索TAM受体在疾病治疗中的治疗潜力。
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