Iida Yoshiyuki, Kamijo Tomoyuki, Kusafuka Kimihide, Omae Katsuhiro, Nishiya Yukio, Hamaguchi Noriko, Morita Kotaro, Onitsuka Tetsuro
Division of Head and Neck Surgery.
Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka.
Laryngoscope. 2018 Dec;128(12):2778-2782. doi: 10.1002/lary.27305. Epub 2018 Oct 16.
Depth of invasion (DOI) in oral carcinoma has been integrated into the primary tumor categories in the current tumor-node-metastasis staging (8th edition). However, there is no standard modality to determine DOI preoperatively. The aims of the present study were to evaluate the accuracy of a preoperative measurement of DOI using ultrasonography (US) for superficial oral tongue carcinomas, and to correlate the values obtained with histologically determined DOI measurements.
We retrospectively analyzed the records of 56 patients with oral tongue carcinoma who underwent intraoral US preoperatively, followed by curative surgery at the Shizuoka Cancer Center Hospital in Japan. For the measurement of DOI with US, our unique technique (water balloon method) was evaluated.
The histologically measured tumor size (maximum diameter) showed a distribution of 7.0 to 40.0 mm (mean, 18.6 mm). The correlation between the US-obtained and histologically obtained DOIs was significant (r = 0.867; P < 0.001). In tumors characterized histologically as superficial (DOI ≤ 5 mm), a significant correlation was observed between US-obtained and histologically obtained DOIs (r = 0.870, P < 0.001). For the entire cohort, the sensitivity and specificity of US assessment of DOI of ≤ 5 mm or > 5 mm were 92.3% and 70.6%, respectively.
Intraoral US provides sufficient accuracy for the measurement of tumor DOI in oral tongue carcinoma and is complementary in assessing superficial lesions.
口腔癌的浸润深度（DOI）已被纳入当前肿瘤-淋巴结-转移分期（第8版）的原发肿瘤分类中。然而，术前尚无确定DOI的标准方法。本研究的目的是评估超声（US）术前测量浅表口腔舌癌DOI的准确性，并将获得的值与组织学确定的DOI测量值进行关联。
我们回顾性分析了56例口腔舌癌患者的记录，这些患者术前接受了口腔内超声检查，随后在日本静冈癌症中心医院接受了根治性手术。对于用US测量DOI，我们评估了独特的技术（水囊法）。
组织学测量的肿瘤大小（最大直径）分布为7.0至40.0毫米（平均18.6毫米）。US获得的DOI与组织学获得的DOI之间的相关性显著（r = 0.867；P < 0.001）。在组织学上特征为浅表性（DOI≤5毫米）的肿瘤中，US获得的DOI与组织学获得的DOI之间观察到显著相关性（r = 0.870，P < 0.001）。对于整个队列，US评估DOI≤5毫米或>5毫米的敏感性和特异性分别为92.3%和70.6%。
口腔内超声在测量口腔舌癌肿瘤DOI方面具有足够的准确性，并且在评估浅表病变方面具有互补性。
4。《喉镜》，2018年，第128卷：2778 - 2782页。
