San Francisco State University, Department of Psychology, 1600 Holloway Avenue, EP239, San Francisco, CA, 94132, USA; University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94103, USA.
Griffith University, Menzies Health Insitute Queensland and School of Applied Psychology, 176 Messines Ridge Road, Mt Gravatt, Queensland, 4122, Australia; Murdoch University, School of Psychology & Exercise Science, 90 South Street, Murdoch, Western Autralia, 6150, Australia.
Psychoneuroendocrinology. 2019 Feb;100:137-144. doi: 10.1016/j.psyneuen.2018.10.002. Epub 2018 Oct 7.
Adolescence is a sensitive developmental period in which substance use can exert long-term effects on important biological systems. Emerging cross-sectional research indicates that problematic alcohol consumption may be associated with dysregulated neuroendocrine system functioning. The current study evaluated the prospective effects of binge drinking in adolescence on cortisol stress reactivity in young adulthood among individuals who had experienced parental divorce in childhood (N = 160; Mean age = 25.55, SD = 1.22; 46.9% Female; 88.8% White Non-Hispanic). Youth completed validated measures of problematic drinking during adolescence (aged 15-19) and participated in a standardized social stress task nine years later in young adulthood. Latent growth modeling was conducted within a structural equation modeling framework. Greater binge drinking during adolescence was associated with a significantly lower cortisol stress response in young adulthood, controlling for young adult drinking, sex, childhood externalizing problems, and socioeconomic status. Findings suggest problematic alcohol consumption during mid-to-late adolescence may have important effects on the neuroendocrine stress response system at subsequent developmental stages.
青春期是一个敏感的发育阶段，在此期间，物质使用会对重要的生物系统产生长期影响。新兴的横断面研究表明，问题性饮酒可能与神经内分泌系统功能失调有关。本研究评估了青少年时期的 binge drinking 对经历过童年父母离异的年轻人成年早期皮质醇应激反应的前瞻性影响（N=160；平均年龄 25.55，标准差 1.22；46.9%为女性；88.8%为白种人非西班牙裔）。青少年（15-19 岁）完成了问题性饮酒的验证性测量，9 年后在成年早期参加了标准化的社会应激任务。在结构方程建模框架内进行了潜在增长建模。在控制了成年饮酒、性别、儿童期外化问题和社会经济地位后，青少年时期 binge drinking 越多，成年早期皮质醇应激反应越低。研究结果表明，青少年中期到后期的问题性饮酒可能对随后的发育阶段的神经内分泌应激反应系统产生重要影响。
