潜伏的爱泼斯坦-巴尔病毒基因组在拉吉细胞中的复制。
Replication of latent Epstein-Barr virus genomes in Raji cells.
作者信息
Adams A
出版信息
J Virol. 1987 May;61(5):1743-6. doi: 10.1128/JVI.61.5.1743-1746.1987.
Abstract
The replication of the 50 to 60 latent, predominantly extrachromosomal, Epstein-Barr virus genomes maintained by the Burkitt-lymphoma-derived Raji cell line was investigated by using a Meselson-Stahl density transfer approach. Samples of DNA isolated from cells cultivated for different periods in bromodeoxyuridine-supplemented medium were fractionated according to density, and the distribution of viral and cellular DNAs among the heavy-, hybrid-, and light-density species was quantitated. The results indicate that the majority of latent Epstein-Barr virus DNA plasmids each replicate once during the cell cycle.
摘要
采用Meselson-Stahl密度转移方法，研究了由伯基特淋巴瘤衍生的Raji细胞系所维持的50至60个潜伏的、主要是染色体外的爱泼斯坦-巴尔病毒基因组的复制情况。从在添加了溴脱氧尿苷的培养基中培养不同时期的细胞中分离出的DNA样本，根据密度进行分级分离，并对重密度、杂交密度和轻密度物种中病毒和细胞DNA的分布进行定量分析。结果表明，大多数潜伏的爱泼斯坦-巴尔病毒DNA质粒在细胞周期中各自复制一次。
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