口鼻部皮肤中的毛囊窦复合体作为狂犬病犬死后诊断材料
Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs.
作者信息
Shiwa Nozomi, Nakajima Chikage, Kimitsuki Kazunori, Manalo Daria Llenaresas, Noguchi Akira, Inoue Satoshi, Park Chun-Ho
机构信息
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23-35-1, Higashi, Towada, Aomori 034-8628, Japan.
Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health, 9002 Research Drive, Filinvest Corporate City, Alabang, Muntinlupa City 1781, Philippines.
出版信息
J Vet Med Sci. 2018 Dec 11;80(12):1818-1821. doi: 10.1292/jvms.18-0519. Epub 2018 Oct 17.
Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.
最近，我们报道了口鼻部皮肤中的滤泡-窦复合体（FSCs）对狂犬病犬的死后诊断很有用。在此，我们比较了检测226只疑似狂犬病犬的大脑和FSCs中病毒抗原的敏感性和特异性，并评估了FSCs是否携带病毒基因组和病毒颗粒。在226个样本中的211个检测到病毒抗原，敏感性和特异性均为100%。在默克尔细胞（MCs）的细胞质中观察到病毒RNA和病毒颗粒。这些结果表明，MCs是病毒感染的靶细胞，FSCs是诊断狂犬病的有用材料。
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