Humar Matjaž, Dobravec Anja, Zhao Xiangwei, Yun Seok Hyun
Condensed Matter Department, J. Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 19, SI-1000, Ljubljana, Slovenia.
Optica. 2017 Sep 20;4(9):1080-1085. doi: 10.1364/OPTICA.4.001080.
Stand-alone laser particles that are implantable into biological tissues have potential to enable novel optical imaging, diagnosis and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid) and poly(lactic acid)-substances approved for medical use-and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially-resonant photonic crystal structure.
可植入生物组织的独立激光粒子具有实现新型光学成像、诊断和治疗的潜力。在此，我们展示了几种生物相容性微激光器及其在生物系统中的激光作用。将染料掺杂的聚苯乙烯珠嵌入角膜并进行光泵浦以产生窄带发射。我们用聚（乳酸 - 乙醇酸）和聚（乳酸）（已获医学应用批准的物质）制造了微珠，并展示了组织内和全血中的激光发射。此外，我们通过自组装成洋葱状径向共振光子晶体结构展示了生物相容性胆固醇衍生物微滴激光器。
