State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Collaborative Innovation Center of Light Manipulations and Applications, Shandong Normal University, Jinan 250358, China.
Sensors (Basel). 2022 Apr 20;22(9):3149. doi: 10.3390/s22093149.
The laser is considered one of the greatest inventions of the 20th century. Biolasers employ high signal-to-noise ratio lasing emission rather than regular fluorescence as the sensing signal, directional out-coupling of lasing and excellent biocompatibility. Meanwhile, biolasers can also be micro-sized or smaller lasers with embedded/integrated biological materials. This article presents the progress in biolasers, focusing on the work done over the past years, including the molecular, cellular, tissue, and organism levels. Furthermore, biolasers have been utilized and explored for broad applications in biosensing, labeling, tracking, bioimaging, and biomedical development due to a number of unique advantages. Finally, we provide the possible directions of biolasers and their applications in the future.
激光被认为是 20 世纪最伟大的发明之一。生物激光采用高信噪比激光发射，而不是常规荧光作为传感信号，具有定向激光外耦合和良好的生物相容性。同时，生物激光也可以是具有嵌入式/集成生物材料的微尺寸或更小的激光。本文介绍了生物激光的进展，重点介绍了过去几年的工作，包括分子、细胞、组织和生物体水平。此外，由于具有许多独特的优势，生物激光已被广泛应用于生物传感、标记、跟踪、生物成像和生物医学发展。最后，我们提供了生物激光及其未来应用的可能方向。
