回音壁模式激光生物传感综述。
Review of biosensing with whispering-gallery mode lasers.
作者信息
Toropov Nikita, Cabello Gema, Serrano Mariana P, Gutha Rithvik R, Rafti Matías, Vollmer Frank
机构信息
Department of Physics and Astronomy, Living Systems Institute, University of Exeter, Exeter, EX4 4QD, UK.
Departamento de Química, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, Universidad Nacional de La Plata, La Plata, 1900, Argentina.
出版信息
Light Sci Appl. 2021 Feb 26;10(1):42. doi: 10.1038/s41377-021-00471-3.
Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.
激光是现代光学和传感技术的支柱。基于回音壁模式（WGM）的微激光器尺寸微小，具有适用于生物传感的优异激光特性。WGM激光器已用于单病毒颗粒的无标记检测、生物界面分子静电变化的检测以及条形码式活细胞标记和跟踪。本综述介绍了使用WGM微激光器进行生物传感的最新进展。我们涵盖了WGM谐振器的基本概念、增益介质在各种有源WGM传感器和器件中的集成，以及可与WGM激光器集成的用于生物样品微纳探测的光子器件的前沿进展。
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