Hinterberger W, Mittermayer K, Kinast H, Paukovits W R
Oncology. 1977;34(5):193-7. doi: 10.1159/000225221.
The experiments described in this paper were performed in order to elucidate a possible regulatory role of acute and chronic myeloid leukemic leucocytes. The influence of these cells on either activated or non-activated mouse bone marrow cells was measured, and the results were compared with the action of the two major leucocyte fractions, mononuclear cells and granulocytes. It was demonstrated that acute leukemic blasts were almost completely unable to activate myeloid committed stem cells (Colony Forming Units, CFUC). In contrast, blasts from patients with chronic myeloid leukemia (CML) in blastic crisis disclosed a variable pattern of activation, in that two out of three cases exerted normal stimulatory capacity. A possible inhibitory action of leukemic cells was the subject of further experiments. Acute leukemic blasts in some cases disclosed inhibitory activity, a few cases appeared to be without influence on normal proliferating CFUC. Granulocytes from patients with CML in the chronic phase showed inhibitory capacity when compared with granulocytes from normal individuals. It is apparent from these experiments that leukemic cells themselves may contribute to the regulatory derangements of leukemias.
本文所述实验旨在阐明急性和慢性髓系白血病白细胞可能的调节作用。测定了这些细胞对活化或未活化的小鼠骨髓细胞的影响，并将结果与两种主要白细胞组分，即单核细胞和粒细胞的作用进行了比较。结果表明，急性白血病原始细胞几乎完全无法激活髓系定向干细胞（集落形成单位，CFUC）。相比之下，处于原始细胞危象的慢性髓系白血病（CML）患者的原始细胞表现出可变的激活模式，三分之二的病例具有正常的刺激能力。白血病细胞可能的抑制作用是进一步实验的主题。在某些情况下，急性白血病原始细胞表现出抑制活性，少数病例似乎对正常增殖的CFUC没有影响。与正常个体的粒细胞相比，慢性期CML患者的粒细胞表现出抑制能力。从这些实验可以明显看出，白血病细胞本身可能导致白血病的调节紊乱。
