Department of Oral and Maxillofacial Sciences, Sapienza University of Rome Italy.
J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):1275-1278.
Mesenchymal stem cells (MSCs) are found in high concentrations in several tissues, such as umbilical cord, adipose tissue and dental tissue. Dental stem cells reside in many areas of the oral cavity. Thanks to their abilities, dental stem cells could be used to treat diseases and to understand the basic mechanisms of developmental pathologies. There are currently numerous ongoing clinical trials evaluating a broad spectrum of conditions and situations using different stem cell populations. However, stem cell studies are raising profound ethical questions that weigh on the world of scientific research. Stem cells are always a hot topic in the scientific community. Their use is related also to their banking, as cell manipulation is also often related to medical and ethical issues. Many biomedical studies aim to treat diseases that were previously considered incurable with MSCs. All this has created the need to quickly and safely storage stem cells, usually in a stem cell biobank (SCB). Regenerative medicine is the most important approach for achieving complete tissue regeneration using stem cells isolated from adult tissues, embryonic stem cells, but also through the application of induced pluripotent stem cells (iPSC). iPSCs are non-pluripotent cells that are engineered to acquire the ability to differentiate into all different types of cells. In conclusion, the daily use of stem cells in regenerative procedures is still far from being safe and predictable, especially because of the biomedical component, often requiring experienced biologists and complex technologies for cell manipulation and cell banking. .
间充质干细胞（MSCs）存在于多种组织中，如脐带、脂肪组织和牙齿组织，浓度较高。牙齿干细胞存在于口腔的许多区域。由于它们的能力，牙齿干细胞可以用于治疗疾病和理解发育病理学的基本机制。目前有许多正在进行的临床试验，使用不同的干细胞群体评估广泛的疾病和情况。然而，干细胞研究引发了深刻的伦理问题，这些问题困扰着科学研究领域。干细胞一直是科学界的热门话题。它们的使用与其储存有关，因为细胞操作也常常与医学和伦理问题有关。许多生物医学研究旨在治疗以前认为无法治愈的疾病，使用 MSCs。所有这些都需要快速和安全地储存干细胞，通常是在干细胞生物库（SCB）中。再生医学是使用从成体组织、胚胎干细胞中分离的干细胞，以及通过应用诱导多能干细胞（iPSC）实现完全组织再生的最重要方法。iPSCs 是经过工程设计获得分化为所有不同类型细胞能力的非多能细胞。总之，在再生程序中每天使用干细胞仍然远不安全和可预测，特别是由于生物医学成分，通常需要经验丰富的生物学家和复杂的细胞操作和细胞储存技术。
